The International Society for Clinical Densitometry (ISCD) and the International Osteoporosis Foundation (IOF) convened the FRAX® Position Development Conference (PDC) in Bucharest, Romania, on November 14, 2010, following a two-day joint meeting of the ISCD and IOF on the “Interpretation and Use of FRAX® in Clinical Practice”. These three days of critical discussion and debate, led by a panel of international experts from ISCD, IOF and by dedicated task forces, have clarified a number of important issues pertaining to the interpretation and implementation of FRAX® in clinical practice.

The Official Positions resulting from the PDC are intended to enhance quality and clinical utility of fracture risk assessment worldwide. Since the field of skeletal assessment is new and evolving rapidly, some clinically important issues addressed at the PDCs are not associated with robust medical evidence. Accordingly, some Official Positions are based largely on expert opinion. Despite limitations inherent in any process such as this, ISCD and IOF believe it is important to provide clinicians and technologists with the best distillation of current knowledge in the discipline of bone densitometry and provide guidance to the scientific community on where further research is needed to resolve areas of ambiguity and/or ongoing controversy.